With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.
55750-48-6, A 250 ml 3-neck flask equipped with a magnetic stirring bar and inside thermometer was charged with 80 ml of saturated sodium bicarbonate solution and 1.84 g (13.5 mmol) of 5-(amino-3-thiavaleric acid, TFA salt (Z2). The solution was cooled to 0 C. by means of an ice-salt bath. Then, 2,5-dioxo-2,5-dihydropyrrol-1-carboxylic acid methyl ester (2.09 g, 13.5 mmol) was added in one portion. The cooled reaction mixture was stirred for 30 minutes. The ice bath was removed and the reaction stirred for additional 3 h at ambient temperature. The reaction mixture was acidified to pH 2 with 1 N hydrochloric acid under constant cooling. The aqueous phase was extracted three times with diethyl ether (250 ml). The combined organic phases were washed twice with 150 ml of sodium bicarbonate solution and once with 150 ml of brine. The organic layer was dried over sodium sulfate and evaporated under reduced pressure without heating. The resulting solid was dissolved in 30 ml of methanol and crystallized at -18 C. The precipitate was filtered, washed with cold hexane and dried to give 1.97 g (9.15 mmol, 69%) of an off-white solid. (1154) 1H-NMR: (MeOD, 200 MHz) delta=6.87 (s, 2H); 3.79 (t, J=6.6 Hz, 2H); 3.31 (s, 2H); 2.89 (t, J=6.6 Hz, 2H). (1155) TLC (hexane/ethyl acetate 1:1): Rf=0.40.
The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Fresenius Kabi Deutschland GmbH; Knoller, Helmut; Heckmann, Dominik; Hacket, Frank; Zander, Norbert; Nocken, Frank; Lahiri, Saswata; Gupta, Nitin; Sanghani, Sunil; Abul, Azim; Singh, Hemant Kumar; Grewal, Sandeep; Kaur, Sandeep; US2015/297738; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem