55750-48-6, Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
55750-48-6, Preparation of Intermediate 4-(4-(2, 5-dioxo-2 , 5-dihydro- 1H-p yrrol- 1-yI)butyl)- 1, 2,4-triazolidine-3,5-dione (I-14b):To 4-(4-aminobutyl)-1 ,2,4-triazolidine-3,5-dione hydrochloride (I-i 4a: 42 mg, 0.201 mmol) in NaHCO3 sat aqueous solution (1.006 mL) at 0C was added N-methoxycarbonylmaleimide (31.2 mg, 0.20 1 mmol). The mixture was stirred at 0C for 1 h, and then at room temperature for 2h. The mixture was purified by preparative hplc (0-60% CH3CN(0.1 %TFA in H20)), and then lyophilized, giving 4-(4-(2,5-dioxo-2,5-dihydro-1 H-pyrrol1-yl)butyl)-1,2,4-triazolidine-3,5-dione (l-14b: 10 mg, 20%) a white solid. LC-MS (M+1) 253.3,= 0.89 minute. 1H NMR (400 MHz, CD3CN) 6 ppm 1.51 – 1.62 (m, 4 H) 3.45 (t, J=6.44 Hz, 2 H)3.49 (t, J=6.44 Hz, 2 H) 6.76 (s, 2 H) 7.52 (br. s., 2 H).
As the paragraph descriping shows that 55750-48-6 is playing an increasingly important role.
Reference£º
Patent; NOVARTIS AG; ADAMO, Roberto; ALLAN, Martin; BERTI, Francesco; DANIELI, Elisa; HU, Qi-Ying; WO2013/9564; (2013); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem