With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.
Benzyl 2H-pyrrole-l(5H)-carboxylate (25 g, 0.12 mol) was dissolved in DCM (500 mL) at 00C. m-CPBA (42 g, 0.24 mol) was added in portions at 00C, and the mixture was stirred at RT for 3 days. The reaction mixture was filtered, and the filtrate was washed Na2S2O3 (3 M, 100 mL), NaHCO3 (1 M, 100 mL) and brine (100 mL). The organic layer was dried over Na2SO4 and purified by silica gel chromatography (PE : EtOAc = 10:1) to afford the product benzyl 6-oxa-3-aza-bicyclo[3.1.0]hexane-3- carboxylate (10 g, 37%) as a pale yellow oil. 1H NMR (400 MHz, CDCl3): delta 7.39-7.26 (m, 5H), 5.11 (d, 2H), 3.83 (dd, 2H), 3.68 (d, 2H), 3.39 (dd, 2H).
31970-04-4, As the paragraph descriping shows that 31970-04-4 is playing an increasingly important role.
Reference£º
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
Pyrroline – Wikipedia
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