With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.
[4708] 6 mg (7.12 f.tmol) of this intermediate were taken upin 1 ml of dioxane and then admixed with 6.6 mg (42.7 flillOI)of methyl 2,5-dioxo-2,5-dihydro-lH-pyrrole-1-carboxylateand with 5 fll of saturated aqueous sodium hydrogencarbonatesolution. The reaction mixture was stirred at RT for 1 h.Then another 3 portions each of 50 fll of the saturated aqueoussodium hydrogencarbonate solution were added, and thereaction mixture was stirred at RT for another 30 min. Thenthe reaction mixture was acidified to pH 2 with trifluoroaceticacid and subsequently concentrated in vacuo. The remainingresidue was purified by means of preparative HPLC. Afterlyophilization from acetonitrile/water, 4 mg (60% of theory)of the title compound were obtained as a foam.[4709] HPLC (Method 12): R,=l.9 min;[4710] LC-MS (Method 11): R,=0.88 min; MS (ESipos):mz=923 (M+Hr.
55750-48-6, 55750-48-6 Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 580610, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem