With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.298690-72-9,2-(3-Fluorophenyl)pyrrolidine,as a common compound, the synthetic route is as follows.
e (RS)-2-(3-Fluoro-phenyl)-1-(toluene-4-sulfonyl)-pyrrolidine To a stirred solution of (RS)-2-(3-fluoro-phenyl)-pyrrolidine (0.24 g, 1.45 mmol) and triethylamine (0.40 ml, 2.87 mmol) in dichloromethane (40 ml) was added at 0 C. toluene-4-sulfonyl chloride (0.42 g, 2.20 mmol). The mixture was stirred at RT for 16 h, evaporated, dissolved in water (40 ml) and extracted with ethyl acetate (2*40 ml). The combined organic layers were washed with water (40 ml), brine (40 ml), dried (MgSO4) and evaporated. The crude product was purified by crystallization from ethyl acetate/hexane to give the product (0.38 g, 83%) as a white solid, m.p. 116 C. and MS: m/e=319 (M+)., 298690-72-9
As the paragraph descriping shows that 298690-72-9 is playing an increasingly important role.
Reference£º
Patent; Hoffmann- La Roche Inc.; US6284785; (2001); B1;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem