With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.383127-22-8,2-(4-Bromophenyl)pyrrolidine,as a common compound, the synthetic route is as follows.
A mixture of 2-(4-bromophenyl)pyrrolidine (50.0 mg, 221 pmol, 1.00 equiv), di-/er/- butyl dicarbonate (57.9 mg, 265 pmol, 1.20 equiv) and dimethylaminopyridine (2.70 mg, 22.1 pmol, 0.10 equiv) in tetrahydrofuran (1.00 mL) was purged with nitrogen and then was stirred at 25 C for 2 h. The mixture was filtered and concentrated under reduced pressure. The resultant residue was purified by prep-TLC (Si02, petroleum ether/ethyl acetate = 10/1) to afford tert- butyl 2-(4-bromophenyl)pyrrolidine-l-carboxylate (55.0 mg, 163 pmol, 73.6% yield, 96.5% purity) as a yellow oil. LC-MS [M-55]: 272.1.
383127-22-8, As the paragraph descriping shows that 383127-22-8 is playing an increasingly important role.
Reference£º
Patent; MIRATI THERAPEUTICS, INC; MARX, Matthew, Arnold; LEE, Matthew, Randolph; BOBINSKI, Thomas, P.; BURNS, Aaron, Craig; ARORA, Nidhi; CHRISTENSEN, James, Gail; KETCHAM, John, Nichael; (225 pag.)WO2019/152419; (2019); A1;,
Pyrrolidine – Wikipedia
Pyrrolidine | C4H9N – PubChem