Month: October 2020

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4 (8.53 g, 0.055 mol) was refluxed for 1 hour in thionyl chloride (40 mL).Evaporate excess thionyl chloride,The intermediate acid chloride was obtained as a dark oil.20 degrees,The oil was dissolved in dichloromethane (30 mL).And slowly added dropwise to a solution of amino compound 3 (11.66 g, 0.05 mol) and triethylamine (10.12 g, 0.1 mol) in dichloromethane (70 ml).Stirring was continued for 2 hours.The reaction solution was washed with dilute hydrochloric acid and 5% aqueous sodium hydroxide solution, respectively.The organic phase is concentrated and dried,The resulting residue was dissolved in isopropanol (60 ml) at 50 C.36% hydrochloric acid (25.35 g, 0.25 mol) was added dropwise, and stirring was continued for 2 hours.Slowly add water (100 ml),Cool to 5 degrees to precipitate a light solid.filter,The filter cake is washed with cold water.The filter cake was dried to obtain 12.57 g of product 5,The yield was 80%., 25021-08-3

As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Patent; Guangzhou Zhenlaimai New Materials Technology Co., Ltd.; Wang Ruidong; Xiao Juan; (11 pag.)CN108892631; (2018); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1122-10-7, 3,4-Dibromo-1H-pyrrole-2,5-dione is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of 2,3-dibromo-N-isobutane-maleimide:Dissolve 200 mg of sodium hydride in 10 mL of N, N-dimethylformamide in an ice-water bath.Dissolve 600mg of 2,3-dibromomaleimide in 10mLN, N-dimethylformamide was added dropwise to sodium hydride,After stirring for 30min, 1-bromo-2-methylpropane was added, and the reaction was heated to 60 C for 1h.Quenched by saturated ammonium chloride after cooling,Ethyl acetate extraction, drying over anhydrous sodium sulfate, concentration, column chromatography403 mg of product was obtained., 1122-10-7

The synthetic route of 1122-10-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Physics And Chemistry Technology Institute; Wang Ying; Wang Ruifang; Wang Pengfei; Liu Yanwei; Wei Xiaofang; Liu Jianjun; Li Zhiyi; Hu Xiaoxiao; (24 pag.)CN110551054; (2019); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151038-94-7,6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate,as a common compound, the synthetic route is as follows.

151038-94-7, [4593] 8 mg (7.5 f.tmol) ofN-(3-carboxypropyl)-N-methylL-valyl-N -[ (3R,4S,5S)-3-methoxy-1-{ (2S)-2-[ (1 R,2R)-1-methoxy-2-methyl-3-oxo-3-{ [ (2S,3E)-1-phenyl-4-( 4-sulphophenyl)but-3-en-2-yl]amino }propyl]pyrrolidin-1-yl }-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, 2.8 mg(8.2 f.tmol) of 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazidetrifluoroacetate, 3.4 mg (9 f.tmol) ofHATU and3.9 fll ofHunig’s base were stirred in 0.77 ml ofDMF at RTfor 20 h. Subsequently, the reaction mixture was purified bymeans of preparative HPLC.[4594] 3 mg (31% of theory) of the title compound wereobtained.[4595] LC-MS (Method 1): R,=0.90 min; MS (ESipos):m/z=1164 (M+Ht

151038-94-7 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanehydrazide 2,2,2-trifluoroacetate 23509306, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

To a stirred solution of 2,3-dibromomaleimide (0.255 g, 1.0mmol) in tetrahydrofuran (4 ml) N-methylmorpholine (76 mul, 1.1mmol) and methyl chloroformate (85 mul, 1.1mmol) were added at 0 C. When TLC (nhexane:acetone=8:2) showed complete conversion of the starting material(3 h), the reaction mixture was diluted with CH2Cl2, filtered through a pad ofCelite and evaporated. The obtained crude 4 (0.308 g) was reacted, withoutpurification, with t-butyl mercaptan 2g (237 mul, 2.1mmol) according to generalmethod A to give compound 6g (0.150 g). The crude product was used forfurther step without purification.

1122-10-7, As the paragraph descriping shows that 1122-10-7 is playing an increasingly important role.

Reference£º
Article; Csavas, Magdolna; Miskovics, Adrienn; Szcs, Zsolt; Rth, Erzsebet; Nagy, Zsolt L; Bereczki, Ilona; Herczeg, Mihaly; Batta, Gyula; Nemes-Nikodem, Eva; Ostorhazi, Eszter; Rozgonyi, Ferenc; Borbas, Aniko; Herczegh, Pal; Journal of Antibiotics; vol. 68; 9; (2015); p. 579 – 585;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1122-10-7,3,4-Dibromo-1H-pyrrole-2,5-dione,as a common compound, the synthetic route is as follows.

General procedure: Dried pressure tube was charged with magnetic stir bar and50 mg of PdSiO2 catalysts (1 mol% with respect to amine). Then,1.0 mL o-xylene was added, followed by the addition of 0.5 mmolof amine and 1 mmol of benzyl alcohol. The pressure tube wasflushed with argon was closed with screw cap. Then it was placedin the preheated aluminum block and reaction was allowed to progressfor 30 h at 150 C. After completion of the reaction, pressuretube was removed from aluminum block and cooled down to roomtemperature. The catalyst was filtered out by ciliate and reactionproducts were analyzed by GC-MS and the corresponding amineswere purified by column chromatography. The yields of selectedamines were determined by GC analysis using n-hexadecane asstandard. For this purpose, after completion of the reaction, nhexadecane(100 mL) as standard was added to the reaction pressuretube and the reaction products were diluted with ethyl acetate followed by filtration using plug of silica and then subjected GCanalysis., 1122-10-7

1122-10-7 3,4-Dibromo-1H-pyrrole-2,5-dione 14279, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Article; Alshammari, Ahmad S.; Natte, Kishore; Kalevaru, Narayana V.; Bagabas, Abdulaziz; Jagadeesh, Rajenahally V.; Journal of Catalysis; vol. 382; (2020); p. 141 – 149;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

25021-08-3, 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetyl]-L-valyl-N-{3-[{(1R)-1-[1-benzyl-4-(2,5-difluorophenyl)-1H-pyrrol-2-yl]-2,2-dimethylpropyl}(glycoloyl)amino]propyl}-L-alaninamide The title compound was prepared from Example M9 first by coupling to N-[(benzyloxy)carbonyl]-L-valyl-L-alanine in the presence of HATU and N,N-diisopropylethylamine. In the next step, the Z protecting group was removed by hydrogenating over 10% palladium on activated carbon at RT under hydrogen standard pressure for 1 hour and then converting the deprotected intermediate to the title compound by coupling to (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid in the presence of HATU and N,N-diisopropylethylamine. LC-MS (Method 1): Rt=1.21 min; MS (ESIpos): m/z=777 (M+H)+., 25021-08-3

As the paragraph descriping shows that 25021-08-3 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; MARX, Leo; JOHANNES, Sarah Anna Liesa; STELTE-LUDWIG, Beatrix; DIETZ, Lisa; TERJUNG, Carsten; MAHLERT, Christoph; GREVEN, Simone; SOMMER, Anette; BERNDT, Sandra; (481 pag.)US2019/77752; (2019); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

1334177-86-4, 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-(3-Dimethylaminopropyl)-N’-ethylcarbodiimide (28 mg, 0.146 mmol, 1 eq) was added to a solution of 105 (203 mg, 0.146 mmol) and maleimide-PEG8 acid (87 mg, 0.146 mmol) in chloroform (5 mL). The reaction was stirred for 1 .5 h then diluted with chloroform (50 mL), washed with water (50 mL), brine (30 mL), dried over magnesium sulphate, filtered and evaporated. Flash chromatography [gradient elution 100% DCM to 90% DCM/10% methanol] gave 106 as a pale yellow solid (205 mg, 72%). LC/MS: RT 5.75 min; MS (ES+) m/z (relative intensity) 982.90 (100), 1963.70 (5).

1334177-86-4, As the paragraph descriping shows that 1334177-86-4 is playing an increasingly important role.

Reference£º
Patent; VAN BERKEL, Patricius Hendrikus Cornelis; HOWARD, Philip Wilson; (281 pag.)WO2016/166341; (2016); A1;; ; Patent; VAN BERKEL, Patricius Hendrikus Cornelis; HOWARD, Philip Wilson; (280 pag.)WO2016/166307; (2016); A1;; ; Patent; VAN BERKEL, Patricius Hendrikus Cornelis; HOWARD, Philip Wilson; (280 pag.)WO2016/166300; (2016); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

6913-92-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6913-92-4,1-Benzyl-3-pyrroline,as a common compound, the synthetic route is as follows.

N-Benzyl-3-pyrroline 2 (504 muL, 2.64 mmol) was added to a solution of ethyl chlorooximidoacetate (1 g, 6.62 mmol, 2.5 eq) in toluene (20 mL). The flask was heated to 110 C (oil bath) while a solution of Et3N (276.8 muL, 19.8 mmol, 7.5 eq) in toluene (15 mL) was added over 16 hh using a syringe pump. After concentration under reduced pressure, the crude product was purified by silica gel column chromatography (4:1 petroleum ether/EtOAc) to afford compound (+-)-20 (370 mg, 1.35 mmol, 51%). Yellow oil Rf = 0.52 (7:3 petroleum ether/EtOAc). 1H NMR (400 MHz, CDCl3): delta 7.26 (m, 5H, phenyl), 5.20 (dd, 1H, J5,4 = 4.5 Hz, J3,4 = 9.6 Hz, H-4), 4.31 (2 complex q, 2H, J = 7.2 Hz, diastereotopic OCH2), 3.91 (dt, 1H, J2′,3 = 1.0 Hz, J2,3 = 7.1 Hz, J3,4 = 9.5 Hz, H-3), 3.68 (d, 1H, 2J = 13.3 Hz, NCH2Ph), 3.55 (d, 1H, 2J = 13.3 Hz, NCH2Ph), 3.24 (d, 1H, 2J = 11.2 Hz, H-5′), 3.19 (d, 1H, 2J = 9.9 Hz, H-2′), 2.44 (dd, 1H, J2,3 = 7.2 Hz, 2J = 9.8 Hz, H-2), 2.37 (dd, 1H, J5,4 = 4.6 Hz, 2J = 11.2 Hz, H-5), 1.31 (t, 3H, J = 7.2 Hz, Me). 13C NMR (100 MHz, CDCl3): delta 160.7, 152.2 (C=N, C=O), 137.8 (C-ar), 128.5 (2CH-ar), 128.2 (2CH-ar), 127.1 (1CH-ar), 87.4 (C-4), 61.9 (OCH2), 61.1 (C-5), 58.3 (CH2 benzyl), 56.9 (C-2), 51.0 (C-3), 14.1 (CH3). MS m/z = 274.13 for C15H18N2O3; MS-ESI positive mode: 275.1 [M+H]+, 297.1 [M+Na]+.

The synthetic route of 6913-92-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cecioni, Samy; Aouadi, Kaiss; Guiard, Julie; Parrot, Sandrine; Strazielle, Nathalie; Blondel, Sandrine; Ghersi-Egea, Jean-Francois; Chapelle, Christian; Denoroy, Luc; Praly, Jean-Pierre; European Journal of Medicinal Chemistry; vol. 98; (2015); p. 237 – 249;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.205444-34-4,(S)-tert-Butyl 2-(hydroxymethyl)-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

Boron tribromide (BBr3 12 ml; 1 M in CH2Cl2) was slowly added to a stirred solution of 3-Iodo-5-methoxypyridine (10, 471 mg; 2 mmol) in CH2Cl2 (10 ml) at -40 C (dry ice bath) and reaction mixture was left overnight stirring with gradual warming to ambient temperature. MeOH (7 ml) was slowly added and the reaction mixture was refluxed for 2 h. After removal of solvent, water was added and pH was adjusted to 7-8 by adding Na2CO3. The reaction mixture was extracted with EtOAc, dried over Na2SO4 and concentrated to yield crude product which was purified by prep-TLC using EtOAc/hexanes (1:3) to furnish 3-iodo-5-hydroxypyridine, 11 (300 mg, 68%) as a solid compound. To a solution of 6 (0.20 g, 1.0 mmol), 3-iodo-5-hydroxypyridine (11, 0.24 g, 1.1 mmol) and triphenylphosphine (0.40 g, 1.5 mmol) in THF (10 mL), stirred under argon and cooled at 0 C, was added diisopropyl azodicarboxylate (DIAD; 0.3 mL, 1.5 mmol). The reaction mixture was allowed to come up to ambient temperature over a period of 2 h and was stirred overnight. The reaction mixture was evaporated to dryness and the residue was purified by preparative TLC (30% EtOAc in hexane) to give pure product 12 (0.20 g, 50%) as an oil. 1H NMR (500 MHz, CDCl3) delta ppm: 8.41(d, J = 15.0, 1H, PyH), 8.25 (d, J = 2.0, 1H, PyH), 7.56 (d, J = 18.5, 1H, PyH), 5.88 (m, 2H, olefinic), 4.80 (m, 1H, CH-CH2), 4.34-3.95 (m, 4H, O-CH2, N-CH2), 1.48 (s, 9H, Boc). MS, m/z, 403 (100%, [M+H]+).

205444-34-4, As the paragraph descriping shows that 205444-34-4 is playing an increasingly important role.

Reference£º
Article; Pandey, Suresh K.; Pan, Shawn; Kant, Ritu; Kuruvilla, Sharon A.; Pan, Min-Liang; Mukherjee, Jogeshwar; Bioorganic and Medicinal Chemistry Letters; vol. 22; 24; (2012); p. 7610 – 7614;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17057-04-4,4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid,as a common compound, the synthetic route is as follows.

23.0 mL (2216.4 mmol) of toluene, 5.0 g (22.8 mmol) of 4-maleimidebenzoic acid, 2.2 mL (30.4 mmol) of thionyl chloride, and 4 mL of toluene were placed in a 100 mL three-necked flask equipped with a stirrer and a cooling tube,0.36 mL (4.6 mmol) of N, N-dimethylformamide was added,And the mixture was stirred at 80 DEG C for 1 hour in a nitrogen atmosphere to complete the chlorination reaction. Thereafter, the volatile components were removed by distillation under reduced pressure,Maleimide benzoic acid chloride was obtained as yellowish white crystals.Then, 5.4 g (22.8 mmol) of the obtained 4-maleimide benzoic acid chloride,40.0 mL (353.7 mmol) of O-dichlorobenzene,2.0 g (5.7 mmol) of the compound (1)3.2 mL (22.8 mmol) of triethylamine was stirred for 1 hour while heating at 80 DEG C under a nitrogen atmosphere to complete the esterification reaction. Thereafter, the reaction solution was cooled to room temperature, the precipitate was collected, washed with methanol, and dried to obtain 4.1 g (5.5 mmol) of the compound (2) as yellowish white crystals. The obtained compound (2) was identified by chemical analysis to have a chemical structure represented by the following formula (1-1) (molecular weight: 748.7). It was also confirmed that the compound (2) exhibited thermotropic liquid crystallinity by observation under a polarizing microscope. Further, it was confirmed that the compound (2) showed good solubility in DMSO, DMF and NMP.

17057-04-4, The synthetic route of 17057-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Da I Sel Co., Ltd.; Na Ka-ta-ni-, -go-u-ji; I No-u-e-, -ge-i-jo; (17 pag.)KR2018/130526; (2018); A;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem