Brief introduction of 55750-48-6

The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

55750-48-6, [4325] 64 mg (70 flillOI) ofN-(6-aminohexyl)-N-methyl-Lvalyl-N -[ (3R,4S,5S)-3-methoxy-1-{ (2S)-2-[ (1 R,2R)-1-methoxy-2-methyl-3-{ [ (1 S,2R)-1-(1 ,2-oxazinan-2-ylcarbonyl)-2-phenylcyclopropyl]amino }-3-oxopropyl]pyrrolidin-1-yl }-5-methyl-1-oxoheptan-4-yl]-N -methyl-L-valinamide(Intermediate 97) were taken up in 3 ml of 1:1 dioxane/water,then adjusted to pH 9 with 4 ml of saturated sodium hydrogencarbonatesolution and subsequently admixed with 16.3mg (11 0 f.tmol) of methyl2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. The reaction mixture was stirred at RT for 1 hand then concentrated in vacuo. Then another 8 mg (55 f.tmol)of methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylatewere added, and the reaction mixture was adjusted again to189Sep.3,2015pH 9 and stirred at RT for another hour. This was followed byconcentration and purification of the remaining residue bymeans of preparative HPLC. At first, 31 mg of an as yetuncyclized intermediate were obtained. 27 mg of this intermediatewere taken up again in 2 ml of 1:1 dioxane/water andthen admixed with 250 fll of saturated sodium hydrogencarbonatesolution. After stirring at RT for 2 hours, the reactionmixture was concentrated, and the residue was purified bymeans of preparative HPLC. After lyophilization, 20 mg(29% of theory) of the title compound were obtained.[4326] HPLC (Method 5): R,=l.96 min;[4327] LC-MS (Method 1): R,=0.97 min; MS (ESipos):rnz=992 (M+Hr.

The synthetic route of 55750-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
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Analyzing the synthesis route of 5264-35-7

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

5264-35-7, 5-Methoxy-3,4-dihydro-2H-pyrrole is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1B (2.1 g, 10 mmol), 194 5-methoxy-3,4-dihydro-2H-pyrrole (1.49 g, 15 mmol) and 4 cetic acid (5 drops) in 170 methanol (12 mL) was heated by microwave at 100 C. for 2 hours. The mixture was concentrated and the residue was purified by column chromatography on silica gel (EtOAc/Pet. Ether, 1/4 to 4/1, v/v) to give 76A (2 g, 76% yield) as a white 195solid: ESI m/z 266.9, 264.9 [M+H]+ ., 5264-35-7

The synthetic route of 5264-35-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Seal Rock Therapeutics, Inc.; BROWN, Samuel David; US2018/291002; (2018); A1;,
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Downstream synthetic route of 31970-04-4

31970-04-4, As the paragraph descriping shows that 31970-04-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31970-04-4,Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

Benzyl 2H-pyrrole-l(5H)-carboxylate (25 g, 0.12 mol) was dissolved in DCM (500 mL) at 00C. m-CPBA (42 g, 0.24 mol) was added in portions at 00C, and the mixture was stirred at RT for 3 days. The reaction mixture was filtered, and the filtrate was washed Na2S2O3 (3 M, 100 mL), NaHCO3 (1 M, 100 mL) and brine (100 mL). The organic layer was dried over Na2SO4 and purified by silica gel chromatography (PE : EtOAc = 10:1) to afford the product benzyl 6-oxa-3-aza-bicyclo[3.1.0]hexane-3- carboxylate (10 g, 37%) as a pale yellow oil. 1H NMR (400 MHz, CDCl3): delta 7.39-7.26 (m, 5H), 5.11 (d, 2H), 3.83 (dd, 2H), 3.68 (d, 2H), 3.39 (dd, 2H).

31970-04-4, As the paragraph descriping shows that 31970-04-4 is playing an increasingly important role.

Reference£º
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
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New learning discoveries about 872-32-2

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

872-32-2, General procedure: 2-Methyl-pyrroline (1equiv.) was added to a suspension of an enzyme (20% weight) in a mixture of toluene/water (20mL/100muL), followed by the addition of benzylamine (1equiv.) and isocyanoester 1 (1equiv.). The mixture was stirred at room temperature. The enzyme and water were filtered off through a funnel containing Celite and MgSO4. The solvent was then evaporated in vacuum. The product was purified by column chromatography (silica gel, DCM/methanol).

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Article; Wilk, Monika; Brodzka, Anna; Koszelewski, Dominik; Madej, Arleta; Paprocki, Daniel; ??d?o-Dobrowolska, Anna; Ostaszewski, Ryszard; Bioorganic Chemistry; vol. 93; (2019);,
Pyrroline – Wikipedia
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Downstream synthetic route of 55750-48-6

As the paragraph descriping shows that 55750-48-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

55750-48-6, 186 mg (555 mumol) of 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoic acid trifluoroacetate were dissolved in 2.6 ml of saturated sodium hydrogencarbonate solution and admixed at 0 C. with 86 mg (555 mumol) of N-methoxycarbonylmaleimide. The reaction mixture was stirred at 0 C. for 40 min and at RT for 1 h, then cooled again to 0 C., adjusted to pH 3 with sulphuric acid and extracted 3¡Á with 25 ml of ethyl acetate. The combined organic phases were dried over magnesium sulphate and concentrated. [1548] 126 mg (75% of theory) of the title compound were obtained. [1549] LC-MS (Method 1): Rt=0.53 min; m/z=302 (M+H)+

As the paragraph descriping shows that 55750-48-6 is playing an increasingly important role.

Reference£º
Patent; Lerchen, Hans-Georg; Hammer, Stefanie; Harrenga, Axel; Kopitz, Charlotte Christine; Nising, Carl Friedrich; Sommer, Anette; Stelte-Luowig, Beatrix; Mahlert, Christoph; Schuhmacher, Joachim; Golfier, Sven; Greven, Simone; Bruder, Sandra; US2015/23989; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

New learning discoveries about 872-32-2

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,872-32-2

General procedure: A mixture of 2-methyl-1-pyrroline (2.8 g, 33.7 mmol) and the corresponding cyclic phosphite 2a-2e (30.6 mmol) were stirred in toluene (5 mL) for 4-6 h at room temperature (conversion was checked by TLC or 31P NMR), the mixture was poured into 30 mL water, slowly acidified to pH 3 with 11 N HCl then quickly extracted with tert-butyl methyl ether (TBME) (3 .x. 20 mL). The aqueous phase was basified to pH 9-10 with NaOH pellets then extracted with CH2Cl2 (4 .x. 20 mL). The combined organic phases were dried over MgSO4, filtered and roto-evaporated to give the crude aminophosphonates 3a-3e as white powders which were then purified by SiO2 column chromatography with eluent CH2Cl2/EtOH 8/1.

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Article; Gosset, Gae?lle; Cle?ment, Jean-Louis; Culcasi, Marcel; Rockenbauer, Antal; Pietri, Sylvia; Bioorganic and Medicinal Chemistry; vol. 19; 7; (2011); p. 2218 – 2230;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Some tips on 55750-48-6

55750-48-6 Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 580610, apyrrolines compound, is more and more widely used in various fields.

55750-48-6,55750-48-6, Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1 -(2-(2-hydroxyethoxy)ethyl)-1 H-pyrrole-2,5-dione To a solution of (2-aminoethoxy)ethanol (2.9 ml, 29.0 mmol) in a saturated aqueous NaHC03 soltuion (150 ml) was added at 0C, N-(methoxycarbonyl)maleimide (4.5 g, 29.0 mmol) and the reaction mixture was stirred at RT for 30mins and then an additional 3h at RT. The reaction was extracted with DCM. The organic layers were combined, dried over Na2SC>4, filtered and concentrated to dryness afforded the title compound as a pale yellow oil in 53% yield; UPLC-MS: Rt = 0.35 mins; MS m/z [M+H]+ 186.0; Method E.

55750-48-6 Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 580610, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; IRM LLC; BARSANTI, Paul A.; CHAMOIN, Sylvie; DOUMAMPOUOM-METOUL, Lionel; GEIERSTANGER, Bernhard Hubert; GROTZFELD, Robert Martin; GUERRO-LAGASSE, Stephanie; JONES, Darryl Brynley; KARPOV, Alexei; LAFRANCE, Marc; NIETO-OBERHUBER, Cristina; OU, Weijia; PIIZZI, Grazia; WO2014/151030; (2014); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Simple exploration of 55750-48-6

55750-48-6, 55750-48-6 Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 580610, apyrrolines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.

[4708] 6 mg (7.12 f.tmol) of this intermediate were taken upin 1 ml of dioxane and then admixed with 6.6 mg (42.7 flillOI)of methyl 2,5-dioxo-2,5-dihydro-lH-pyrrole-1-carboxylateand with 5 fll of saturated aqueous sodium hydrogencarbonatesolution. The reaction mixture was stirred at RT for 1 h.Then another 3 portions each of 50 fll of the saturated aqueoussodium hydrogencarbonate solution were added, and thereaction mixture was stirred at RT for another 30 min. Thenthe reaction mixture was acidified to pH 2 with trifluoroaceticacid and subsequently concentrated in vacuo. The remainingresidue was purified by means of preparative HPLC. Afterlyophilization from acetonitrile/water, 4 mg (60% of theory)of the title compound were obtained as a foam.[4709] HPLC (Method 12): R,=l.9 min;[4710] LC-MS (Method 11): R,=0.88 min; MS (ESipos):mz=923 (M+Hr.

55750-48-6, 55750-48-6 Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 580610, apyrrolines compound, is more and more widely used in various fields.

Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Analyzing the synthesis route of 31970-04-4

31970-04-4, The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.

31970-04-4, Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Part A: Phenylmethyl (cis)-3,4-dihydroxy-1 -pyrrolidinecarboxylate. Phenylmethyl 2,5-dihydro-1/-/-pyrrole-1-carboxylate (commerically-available) (5.07 g, 25 mmol) was dissolved in a mixture of acetone (25 mL) and water (10 ml_). NMO (5.9 g, 50 mmol) was added followed by catalytic OsO4. The reaction was stirred for 19 hours and then quenched by the addition of an aqueous solution of Na2S2psi3. A standard workup followed by silica gel chromatography (3:1 Hexane:ethyl acetate to pure ethyl acetate to 9:1 DCM: MeOH) yielded phenylmethyl (cis)-3,4-dihydroxy-1-pyrrolidinecarboxylate (0.872 g, 15percent) as a clear oil. LCMS: (M+H)+: 237.9.

31970-04-4, The synthetic route of 31970-04-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/61879; (2009); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

New learning discoveries about 872-32-2

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

872-32-2, 2-Methyl-1-pyrroline is a pyrrolines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

872-32-2, Intermediate (i) 2-Methyl-[1 ,3′]bipyrrolidinyl-1 ‘-carboxylic acid tert-butyl esterTo a solution of N-BOC-3-pyrrolidinone (4.22g, 22.9 mmol) and 2- methylpyrroline (1.95 g, 22.9 mmol) (HCI salt was made by addition of 22.9 mL of 1 M HCI in ether into the DCM solution of 2-methylpyrroline, then evaporated) in DCE (60 ml_) was added powdered sodium triacetoxyborohydride slowly under N2 at r.t. The yellowish milky solution was stirred at r.t. overnight. LC/MS – m/z 255 and 199 (base and M-tBu).The reaction was quenched with aq. NaHCO3 solution (100 ml_). The two layers were separated, and the aqueous layer was extracted with DCM (20 ml_ x 2). The combined DCM extracts were washed with sodium bicarbonate (10 ml_), and brine (5 ml_x2), dried (anhydrous potassium carbonate), filtered, and concentrated in vacuo. The crude product was purified on a silica gel column, eluted with DCM and 7.5percent MeOH in DCM to get 5.50 g (yield: 94percent) of the title compound as a liquid. MS: 255 (M+H+); TLC: 0.5 (10percent MeOH in DCM).

As the paragraph descriping shows that 872-32-2 is playing an increasingly important role.

Reference£º
Patent; SANOFI-AVENTIS; GAO, Zhongli; HARTUNG, Ryan; STEFANY, David; WO2010/65798; (2010); A1;,
Pyrroline – Wikipedia
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