With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55750-48-6,Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate,as a common compound, the synthetic route is as follows.,55750-48-6
[ 4313] 30 mg (30 f.tmol) oflntermediate 89 were taken up in2 ml of 1 ,4-dioxane and admixed with 4 ml of saturatedsodium hydrogencarbonate solution and then with 7.5 mg (50f.tmol) of methyl 2,5-dioxo-2,5-dihydro-18-pyrrole-1-carboxylate.The reaction mixture was stirred at RT for 1 handthen concentrated in vacuo. The remaining residue was purifiedby means of preparative HPLC. After lyophilization, 24mg (74% of theory) of the title compound were obtained.[4314] HPLC (Method 5): R,=2.2 min;[4315] LC-MS (Method 1): R,=l.Ol min; MS (ESipos):rnlz=1006 (M+Hr.
55750-48-6 Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate 580610, apyrrolines compound, is more and more widely used in various fields.
Reference£º
Patent; SEATTLE GENETICS, INC.; LERCHEN, Hans-Georg; LINDEN, Lars; SHEIKH, Sherif El; WILLUDA, Joerg; KOPITZ, Charlotte C.; SCHUHMACHER, Joachim; GREVEN, Simone; MAHLERT, Christoph; STELTE-LUDWIG, Beatrix; GOLFIER, Sven; BEIER, Rudolf; HEISLER, Iring; HARRENGA, Axel; THIERAUCH, Karl-Heinz; BRUDER, Sandra; PETRUL, Heike; JOeRISSEN, Hannah; BORKOWSKI, Sandra; US2015/246136; (2015); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem