1334177-86-4, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.1334177-86-4, name is 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid. An updated downstream synthesis route of 1334177-86-4 as follows.
EDCI.HCI (46 mg, 0.24 mmol) was added to a solution of 145 and Mal-PEG8-acid (130 mg,0.22 mmol) in CHCI3 (10 mL) and stirred at room temperature for 2 hr. LC/MS shows 78%starting material present. A further 2 eq EDCI.HCI was added in portions to push the reaction to completion. The reaction mixture was washed with water (10 mL), dried (Biotage PS) and evaporated to dryness, under reduced pressure, to leave a yellow solid which was purified by prep HPLC to leave the product I as an off-white solid (90 mg, 34%yield). LC/MS (method B): retention time 1.47 mins, (ES+) rnlz 1445.9 [M+ H].
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Reference£º
Patent; MEDIMMUNE LIMITED; HOWARD, Philip Wilson; GREGSON, Stephen John; (207 pag.)WO2018/192944; (2018); A1;,
Pyrroline – Wikipedia
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