1334177-86-4, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.1334177-86-4, name is 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid. An updated downstream synthesis route of 1334177-86-4 as follows.
(d) 1-(3-(2, 5-dioxo-2 , 5-dihydro- 1H-pyrrol- 1-yl)propanamido)-N-((S)- 1-(((S)- 1-((4-((S)-7- methoxy-8-((5-(((S)- 7-methoxy-2-(4-(4-methylpiperazin- 1-yl)phenyl)-5-oxo-5, 1 la-dihydro- 1H- benzo[e]pyrrolo[1, 2-a][1, 4]diazepin-8-yl) oxy)pentyl) oxy)-5-oxo-5, 1 la-dihydro- 1H- benzo[e]pyrrolo[1, 2-a][1, 4]diazepin-2-yl)phenyl)amino) – 1-oxopropan-2-yl)amino)-3-methyl- 1- oxobutan-2-yl)-3, 6,9, 12,15, 18,21, 24-octaoxaheptacosan-2 7-amide (91)Piperidine (0.2 mL) was added to a solution of 90 (77 mg, 63.4 pmol) in DMF (1 mL). The reaction mixture was allowed to stir for 20 minutes. The reaction mixture was carefully diluted with DCM (50 mL) and washed with water (50 mL). The organic layers was washed with brine (100 mL), dried over Mg504, filtered and evaporated under reduced pressure to provide the unprotected valine intermediate. The crude residue was immediately redissolved in chloroform (5 mL). Mal(Peg)8-acid (56 mg, 95 pmol) and EDCI (18 mg, 95 pmol) were added, followed by methanol (0.1 mL). The reaction was allowed to stir for 3 hours at room temperature at which point completion was observed by TLC and LC/MS (1.19 mm (ES+) m/z(relative intensity) 784.25 (([M+ 2H]2j/2, 100)). The reaction mixture was diluted with chloroform (50 mL), washed with water (100 mL), dried (MgSO4), filtered and evaporated in vacuo, followed by high vacuum drying, to provide the crude product. Purification by flash chromatography (gradient elution: HPLC grade 96:4 v/v CHCI3/MeOH to 90:10 v/v CHCI3/MeOH) gave 91 as a yellow solid (43 mg, 43%). 1H NMR (400 MHz, ODd3) O 8.73 (5, 1H), 7.88 (dd, J= 7.6, 3.9 Hz, 2H), 7.75 (d, J= 8.6 Hz, 2H), 7.52 (d, J= 2.0 Hz, 2H), 7.44 (5, 1H), 7.40-7.28 (m, 4H), 6.91 (d, J= 8.8 Hz, 2H), 6.81 (5, 2H), 6.69 (5, 2H),6.48 (5, 1 H), 4.72 -4.63 (m, 1 H), 4.46 -4.34 (m, 2H), 4.25 – 4.03 (m, 6H), 3.95 (5, 4H), 3.84 (dd, J = 17.2, 10.1 Hz, 4H), 3.72 -3.46 (m, 30H), 3.44 -3.32 (m, 4H), 3.30-3.20 (m, 4H), 2.75-2.63 (m, 1H), 2.59 (5, 4H), 2.55-2.43 (m, 3H), 2.37 (5, 3H), 2.29 (dd, J= 12.7, 6.7 Hz, 1H), 2.03-1.89 (m, 4H), 1.72 (d, J= 22.7 Hz, 8H), 1.46 (d, J= 7.2 Hz, 3H), 1.01 (dd, J = 11.5, 6.9 Hz, 6H). MS (ES) m/z (relative intensity) 784.25 (([M+ 2H]2)/2, 100).
This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid. We look forward to the emergence of more reaction modes in the future.
Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; VAN BERKEL, Patricius Henrikus Cornelis; HOWARD, Philip Wilson; WILLIAMS, David G; WO2015/159076; (2015); A1;,
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