Discovery of 5-Methoxy-3,4-dihydro-2H-pyrrole

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5264-35-7, An article , which mentions 5264-35-7, molecular formula is C5H9NO. The compound – 5-Methoxy-3,4-dihydro-2H-pyrrole played an important role in people’s production and life.

Saturated Heterocycles, 75 – Preparation of Tetracyclic Thiophene Derivatives with Bridgehead Nitrogen. Synthesis of Polymethylenethieno<2,3-d>dihydropyrrolo-, tetrahydropyrido- and tetrahydroazepino<1,2-a>pyrimidin-4-ones and -4-thiones

The following tetracyclic ring systems and their derivatives have been synthesized for pharmacological investigations: Trimethylenethieno<2,3-d>dihydropyrrolo<1,2-a>pyrimidin-4-one and -4-thione (1a, 5a); Tetramethylenethieno<2,3-d>dihydropyrrolo<1,2-a>pyrimidin-4-one and -4-thione (1b, 1j, 5b); Pentamethylenethieno<2,3-d>dihydropyrrolo<1,2-a>pyrimidin-4-one and-4-thione (1c, 5c); Trimethylenethieno<2,3-d>tetrahydropyrido<1,2-a>pyrimidin-4-one and -4-thione (1d, 5d); Tetramethylenethieno<2,3-d>tetrahydropyrido<1,2-a>pyrimidin-4-one and -4-thione (1e, 5e);Pentamethylenethieno<2,3-d>tetrahydropyrido<1,2-a>pyrimidin-4-one and -4-thione (1f, 5f); Trimethylenethieno<2,3-d>tetrahydroazepino<1,2-a>pyrimidin-4-one and -4-thione (1g,5g); Tetramethylenethieno<2,3-dpyrimidin-4-one and -4-thione (1h, 5h); Pentamethylenethieno<2,3-d>tetrahydroazepino<1,2-a>pyrimidin-4-one and -4-thione (1i, 5i); Tetramethylenethieno<2,3-d>tetrahydroazepino<1,2-a>pyrimidin-4-one (7b); Pentamethylenethieno-<2,3-d>tetrahydropyrido<1,2-a>pyrimidin-4-one (7c).Compounds 1a-i were synthesized from 2-amino-3-ethoxycarbonyl-4,5-polymethylenethiophene 2a-c with the corresponding lactim ethers (3a-c) in chlorobenzene in the presence of polyphosphoric acid (PPA).Compounds 7b and 7c were obtained in the reaction ob beta-amino acid esters 2a and 2c with 2-bromopyridine (6).The thione derivatives (5a-i) were prepared from compounds 1a-i with phosphorus(V) sulphide. – Keywords: Condensation of 2-amino-3-ethoxycarbonyl-4,5-polymethylenethiophene with lactim ethers and 2-bromopyridine; Oxo-thio exchange

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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem