1122-10-7, In an article, published in an article,authors is Castaneda, Lourdes, once mentioned the application of 1122-10-7, Name is 3,4-Dibromo-1H-pyrrole-2,5-dione,molecular formula is C4HBr2NO2, is a conventional compound. this article was the specific content is as follows.
Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation
In this communication we describe a novel acid-cleavable linker strategy for antibody-drug conjugation. Functional disulfide bridging of the single interchain disulfide bond of a trastuzumab Fab fragment yields a homogeneous antibody-drug conjugate bearing a thiomaleamic acid linker. This linker is stable at physiological pH and temperature, but quantitatively cleaves at lysosomal pH to release the drug payload.
1122-10-7, If you are hungry for even more, make sure to check my other article about 1122-10-7
Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem