Month: November 2020

A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.31970-04-4, name is Benzyl 2,5-dihydro-1H-pyrrole-1-carboxylate. An updated downstream synthesis route of 31970-04-4 as follows., 31970-04-4

(i) 3,4-cis-Dihydroxy-pyrrolidine-1-carboxylic acid benzyl ester To a solution of benzyl 3-pyrroline-1-carboxylate (15 g, 90percent, 66.4 mmol) in 100 mL THF and 25 mL water was added osmium tetroxide (10 mL, 2.5 wt. percent solution in 2-methyl-2-propanol, 0.8 mmol) and 4-methylmorpholine N-oxide (8.56 g, 73 mmol) as solid. The mixture was stirred at room temperature overnight and concentrated in vacuo. The residue was re-dissolved in 300 mL ethyl acetate and washed with aqueous Na2SO3 (1.5 g in 100 mL water) solution and aqueous NaHCO3 solution and brine. The combined aqueous layer was extracted once with ethyl acetate (100 mL). The combined organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The crude was further purified by flash column chromatography eluding with 4-5percent MeOH in CH2Cl2 to give 15.26 g product as white solid (97percent yield). 1H NMR (300 MHz, CDCl3) delta7.34 (m, 5H), 5.11 (bs, 2H), 4.26 (m, 2H), 3.66 (m, 2H), 3.41 (m, 2H), 1.56 (bs, 2H).

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Reference£º
Patent; Romines III, William Henry; Kania, Robert Steven; Lou, Jihong; Cripps, Stephan; Zhou, Ru; He, Mingying; US2004/19065; (2004); A1;,
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25021-08-3, The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.25021-08-3, name is 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid. A new synthetic method of this compound is introduced below.

Trifluoroacetic acid/(2S)-2-amino-4-[{(1R)-1-[1-benzyl-4-(2,5-difluorophenyl)-1H-pyrrol-2-yl]-2,2-dimethylpropyl}(glycoloyl)amino]-N-{2-[(2-{[(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetyl]amino}ethyl)sulphonyl]ethyl}butanamide (1:1) The title compound was prepared from Intermediate L81 by coupling with Intermediate C58 in the presence of HATU and N,N-diisopropylethylamine. In the next step, the Z protective group was removed by hydrogenation over 10% palladium on activated carbon in DCM/methanol 1:1 at RT under hydrogen standard pressure for 30 min. The deprotected intermediate was then converted by coupling with (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid in the presence of HATU and N,N-diisopropylethylamine and finally by deprotection with zinc chloride into the title compound. LC-MS (Method 1): Rt=0.83 min; MS (ESIpos): m/z=785 (M+H)+.

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid, you can also browse my other articles.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LERCHEN, Hans-Georg; REBSTOCK, Anne-Sophie; CANCHO GRANDE, Yolanda; WITTROCK, Sven; BERNDT, Sandra; GRITZAN, Uwe; FITTING, Jenny; STELTE-LUDWIG, Beatrix; JONES, Patrick; MAHLERT, Christoph; VOTSMEIER, Christian; SCHOeNFELD, Dorian; TRAUTWEIN, Mark; WEBER, Ernst; PAWLOWSKI, Nikolaus; GREVEN, Simone; GLUeCK, Julian Marius; HAMMER, Stefanie; DIETZ, Lisa; MAeRSCH, Stephan; (357 pag.)US2020/138970; (2020); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.25021-08-3, name is 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid, below Introduce a new synthetic route., 25021-08-3

Then it is possible to obtain the desired compound (I-27) by an esterification reaction using a dehydrating condensing agent such as maleimide acetic acid and dicyclohexylcarbodiimide., 25021-08-3

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid

Reference£º
Patent; DIC CORPORATION; HAYASHI, MASANAO; KUSUMOTO, TETSUO; (30 pag.)JP5648352; (2015); B2;,
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Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.6913-92-4, name is 1-Benzyl-3-pyrroline, below Introduce a new synthetic route., 6913-92-4

6913-92-4, A mixture of 0.675 g (3.14 mMol) 7-bromo-5-fluorobenzofuran, 5.0 g (31.40 mMol)1-benzyl-3-pyrroline, 2.19 mL (12.56 mMol), N,N-diisopropylethylamine, 0.399 g (9.42 mMol) LiCl, 0.154 g (0.66 mMol) tri-2-furylphosphine, and 0.070 g (0.314 mMol) palladium diacetate in 10 mL N,N-dimethylformamide was heated under nitrogen at 100C for 48 hours. The mixture was diluted with 10 mL diethyl ether and filtered through celite. The filtrate was concentrated under reduced pressure and the oily residue was submitted to kugelrohr distillation to remove most of the pyrrole and pyrrolidine side-products. Flash chromatography of the residue (Et3N/Et2O/hexane 1:39:60) yielded 1-benzyl-3-(5-fluorobenzofur-7-yl)pyrrolidine (173 mg, 19%) as a colorless oil. HRMS calculated for C19H19FNO: 296.1450; found: 296.1437

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 1-Benzyl-3-pyrroline

Reference£º
Patent; ELI LILLY AND COMPANY; EP1204659; (2003); B1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

5264-35-7, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5264-35-7, name is 5-Methoxy-3,4-dihydro-2H-pyrrole, below Introduce a new synthetic route.

5264-35-7, To 1-(2,3-dichlorophenyl)-2-(pyridin-3-yl)ethanamine (258 mg, 0.97 mmol) in methanol (5 mL) was added 5-methoxy-3,4-dihydro-2H-pyrrole (96 mg, 0.97 mmol) followed by acetic acid (2 drops). The mixture was heated at 70¡ã C. for 16 hours. The mixture was cooled to room temperature and methanol was removed. Purification by chromatography on silica gel (5percent 7N NH3 in MeOH/CH2Cl2) gave N-(1-(2,3-dichlorophenyl)-2-(pyridin-3-yl)ethyl)-3,4-dihydro-2H-pyrrol-5-amine (161 mg, 50percent) as an off white solid.1H NMR (300 MHz, CD3OD) delta 1.79-1.90 (m, 2H), 2.41-2.49 (m, 2H), 2.87-2.94 (m, 1H), 3.14-3.21 (m, 1H), 3.34-3.41 (m, 2H), 5.28-5.33 (m, 1H), 7.30-7.47 (m, 4H), 7.77-7.81 (m, 1H), 8.36-8.42 (m, 1H), 8.43 (s, 1H).

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 5-Methoxy-3,4-dihydro-2H-pyrrole. We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; ALLERGAN, INC.; US2010/145061; (2010); A1;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.69778-83-2, name is 4-Methoxy-1H-pyrrol-2(5H)-one. An updated downstream synthesis route of 69778-83-2 as follows., 69778-83-2

EXAMPLE 2 (Z)-4-methoxy-5-(cyclohexylmethylene)-3-pyrrolin-2-one (IV, R2 =H, R3 =Me, R4 =cyclohexyl) 23.9 g of 4-methoxy-3-pyrrolin-2-one (94.6 percent) in 1360 ml of 4 n sodium hydroxide solution and 27.5 g of cyclohexanecarbaldehyde (90 to 95 percent) in 330 ml of methanol were reacted as described in Example 1. Data for the product was: Yield: 39.8 g (96.1 percent) Melting point: 134¡ã to 136¡ã C., colorless crystals 1 H-NMR: delta=9.07 (br.s, 1H), 5.32 (d, 1H), 5.14 (d, 1H), 3.83 (s, 3H), 2.40 (m, 1H), 1.09-1.81 (m, 10H)

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Patent; Lonza, Ltd.; US4983743; (1991); A;,
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1-Pyrroline | C4H7N – PubChem

1193-54-0, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.1193-54-0, name is 3,4-Dichloro-1H-pyrrole-2,5-dione. An updated downstream synthesis route of 1193-54-0 as follows.

General procedure: A mixture of 2-(7-methoxynaphthalen-1-yl)ethanamine (compound 3, 101 mg, 0.5 mmol), sodium acetate (82 mg, 1.0 mmol) and cyclic anhydrides 1.0 mmol) in 5mL acetic acid was heated to reflux for 3 h in a round bottomed flask. After the completion of reaction (as evidenced by TLC), the resulting mixture was concentrated under reduced pressure and washed with ethyl acetate (10 mL¡Á3), then the concentrated organic layer was purified by column chromatography on silica gel to obtain pure product., 1193-54-0

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 3,4-Dichloro-1H-pyrrole-2,5-dione. We look forward to the emergence of more reaction modes in the future.

Reference£º
Article; Chang, Ying; Pi, Weiyi; Ang, Wei; Liu, Yuanyuan; Li, Chunlong; Zheng, Jiajia; Xiong, Li; Yang, Tao; Luo, Youfu; Bioorganic and Medicinal Chemistry Letters; vol. 24; 7; (2014); p. 1672 – 1676;,
Pyrroline – Wikipedia
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872-32-2, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.872-32-2, name is 2-Methyl-1-pyrroline. An updated downstream synthesis route of 872-32-2 as follows.

General procedure: Acyl chloride (1.2 mmol, 1.2 equiv) was added to a solution of 4-dimethylaminopyridine (DMAP) (1.2 mmol, 1.2 equiv) in acetonitrile (1.0 mL) at 0 ¡ãC. The reaction was stirred at room temperature for 15 min. A solution of the 5-methyl-3,4-dihydro-2H-pyrrole (1.0 mmol) in acetonitrile (1.0 mL) was added and the reaction was stirred at room temperature for 3 h. p-Toluenesulfonic acid monohydrate (3.0 mmol, 3.0 equiv) was added at 0 ¡ãC under inert atmosphere. The reaction was then stirred at room temperature for 2 h. Arylhydrazine (1.5 mmol, 1.5 equiv) was added and stirred for an addition 5 min at room temperature. The reaction was then heated to 82 ¡ãC for 20 h. The reaction cools down to room temperature. The residue was then dissolved in ethyl acetate and washed with brine and a saturated aqueous solution of NaHCO3. The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give a crude solid, which was purified by column chromatography on silica gel.

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 2-Methyl-1-pyrroline. We look forward to the emergence of more reaction modes in the future.

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Article; Yeo, Se Jeong; Liu, Yongxiang; Wang, Xiang; Tetrahedron; vol. 68; 3; (2012); p. 813 – 818;,
Pyrroline – Wikipedia
1-Pyrroline | C4H7N – PubChem

Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.1334177-86-4, name is 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid, below Introduce a new synthetic route., 1334177-86-4

A solution of Super-Hydride (0.37 ml_, 1 M in THF) was added dropwise to a solution of SEM- dilactam 4 (200 mg, 0.15 mmol) in dry THF (5 ml_) at -78C under an argon atmosphere. The addition was completed over 5 minutes in order to maintain the internal temperature of the reaction mixture constant. After 40 minutes, an aliquot was quenched with water for LC/MS analysis, which revealed that the reaction was complete. Water (20 mL) was added to the reaction mixture and the cold bath was removed. The organic layer was extracted with CH2CI2 (3 x 50 mL) and the combined organics were washed with brine (100 mL), dried with MgS04, filtered and the solvent removed by rotary evaporation under reduced pressure. The crude product was dissolved in dry CH2CI2 in a round bottom flask purged with argon. Mal-dPEGs-OH acid (31.4 mg, 0.148 mmol) and EDCI.HCI (28.5 mg, 0.148 mmol) were added and the mixture was left to stir at room temperature until complete. The crude material was purified by reverse phase HPLC to afford product 6 with 82% purity (37 mg, 1 1 % yield). LC/MS 1.38 min (ES+) m/z = 1 101 .05 [Af + 2H]2+- ; LC/MSismin 5.84 min (ES+) m/z = 1 101.05 [Af + 2H]2+ ., 1334177-86-4

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13,16,19,22,25,28-octaoxa-4-azahentriacontan-31-oic acid

Reference£º
Patent; MEDIMMUNE LIMITED; HOWARD, Philip Wilson; MASTERSON, Luke; CAILLEAU, Thais; DIMASI, Nazzareno; WHITE, Jason; (71 pag.)WO2019/96788; (2019); A1;,
Pyrroline – Wikipedia
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The molecularity of an elementary reaction is the number of molecules that collide during that step in the mechanism. If there is only a single reactant molecule in an elementary reaction, that step is designated as unimolecular.55750-48-6, name is Methyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate. A new synthetic method of this compound is introduced below., 55750-48-6

To a solution of S7 (53 mg, 0.082 mmol) in a saturated solution of NaHCO3 (3.5 mL) was added finely ground N-methoxycarbonylmaleimide (105 mg, 0.677 mmol) under vigorous stirring. After 30 min at 0 C., the mixture was diluted with THF (3.5 mL) and warmed to room temperature. After 1 h, the mixture was acidified to pH 1-2 with an aqueous solution of 1.0 M H2SO4 and extracted with EtOAc (2¡Á20 mL). The combined organic layers were dried over Na2SO4, filtered, and concentrated. Purification by normal phase chromatography (90:10:0.6:0.6 CH2Cl2:MeOH:AcOH:H2O) gave S8 (42 mg, 71%) as a yellow solid. Data for S8: Rf 0.20 (90:10:0.6:0.6 CH2Cl2:MeOH:AcOH:H2O); mp>230 C. dec; [alpha]D=-14.0 (c 0.1, in MeOH); UV lambdamax (MeOH): 365 nm; IR: 3249, 3186, 2928, 1753, 1708, 1687, 1651, 1520 cm-1; 1H NMR (DMSO-d6, 500 MHz) delta 10.61 (s, 1H), 10.31 (s, 1H), 8.19 (m, 1H), 7.84 (d, 4H, J=9 Hz), 7.79 (d, 2H, J=9 Hz), 7.75 (d, 2H, J=9 Hz), 7.16 (s, 2H), 7.10 (d, 2H, J=8 Hz), 4.32 (s, 2H), 3.82 (m, 1H), 3.64 (s, 2H), 2.35 (m, 1H), 2.15 (m, 2H), 1.93 (m, 1H), 1.59 (m, 1H), 1.49 (m, 3H), 1.42 (m, 1H), 1.36 (s, 9H); 13C NMR (DMSO-d6, 125 MHz) delta 176.1, 174.2, 172.5, 170.7, 168.4, 166.6, 155.7, 147.9, 147.6, 141.7, 141.1, 135.0, 123.5, 123.4, 119.5, 119.3, 78.0, 52.4, 42.8, 41.4, 40.5, 45.0, 32.8, 32.1, 28.2, 22.9; LRMS (ESI)- Calc for C34H38N7O11 (M-H)-: 720.3. Found: 720.3.

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Reference£º
Patent; The Regents of the University of California; Isacoff, Ehud Y.; Kramer, Richard H.; Trauner, Dirk; Banghart, Matthew R.; Volgraf, Matthew; Langa, Pablo Ignacio Gorostiza; Borges, Katharine; US9097707; (2015); B2;,
Pyrroline – Wikipedia
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