17057-04-4, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 17057-04-4, Name is 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-benzoicacid, molecular formula is C11H7NO4. In a Article, authors is Nascimento-Junior, Nailton M.£¬once mentioned of 17057-04-4
Microwave-assisted synthesis and structure-activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives
We described herein the optimization of the synthetic methodology exploited to obtain the pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine sedative prototype 1a and novel analogues designed by successive molecular simplifications. By applying microwave irradiation during the hetero Diels-Alder key-step to obtain the heterotricyclic scaffold, under solvent-free conditions, we were able to obtain the desired compounds in drastically shorter times and better yields. Additionally, in vivo evaluation of the sedative effects of these heterocyclic derivatives showed that 1a and the novel structurally-related analogue 1e were the most efficient compounds to impair the locomotor activity in mice at the dose of 10 mumol/kg.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.17057-04-4. In my other articles, you can also check out more blogs about 17057-04-4
Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem