5264-35-7, Name is 5-Methoxy-3,4-dihydro-2H-pyrrole, belongs to pyrrolines compound, is a common compound. 5264-35-7In an article, authors is Adams, Mark E., once mentioned the new application about 5264-35-7.
Design and synthesis of orally available MEK inhibitors with potent in vivo antitumor efficacy
The structure-based design, synthesis, and biological evaluation of two novel series of potent and selective MEK kinase inhibitors are described herein. The elaboration of a lead pyrrole derivative to a bicyclic dihydroindolone core provided compounds with high potency and good drug-like pharmaceutical properties. Further scaffold modification afforded a series of dihydroindolizinone inhibitors, including an orally available advanced preclinical MEK inhibitor with potent in vivo antitumor efficacy.
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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem