Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C11H9NO3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1081-17-0
Screening of bioactive components from traditional Chinese medicine by immobilized beta2 adrenergic receptor coupled with high performance liquid chromatography/mass spectrometry
Traditional Chinese medicine (TCM) represents a valuable resource for lead compounds discovery. Given the complexity of TCM components, analytical methods play a key role in novel drug development. In our study, we established a high specific and reliable bio-active components screen system, where beta2 adrenergic receptor (beta2-AR) was immobilized on silica by non-covalent bonds and packed into a stainless steel column (4.6 ¡Á 50 mm, 7 mum) to form beta2-AR chromatography column. The column was further coupled with high performance liquid chromatography-time of flight tandem mass spectrometry (TOF-MS/MS). By utilizing this strategy, we successfully identified four beta2-AR-targeting compounds: tetrahydroberberine, tetrahydrocolumbamine, fumarine and corydaline from Corydalis Rhizome. The association constants between beta2-AR and tetrahydroberberine (9.04 ¡Á 104/M) as well as fumarine (4.30 ¡Á 104/M) were determined by frontal chromatography. We also found that these two compounds shared the identical binding site on immobilized beta2-AR with corresponding concentrations of 6.67 ¡Á 10?4 M and 5.88 ¡Á 10?4 M, respectively. The newly established method represents an efficient tool to identify the target specific natural compounds.
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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem