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An approach to alicyclic ring-fused xanthines
A convenient three-step approach to the synthesis of five to eight-membered alicyclic ring-fused xanthines was developed. The method included reaction of lactim or thiolactim ethers with 6-aminouracils, followed by bromination and copper-catalyzed arylation. The procedure allowed preparation of the title compounds in 21-36% overall yields.
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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem