Related Products of 1081-17-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1081-17-0, Name is 1-(4-Methoxyphenyl)-1H-pyrrole-2,5-dione, molecular formula is C11H9NO3. In a Article£¬once mentioned of 1081-17-0
Distrubution and excretion of protopine in rats by RP-HPLC method
AIM: To study the distrubution and excretion of protopine in rats. METHODS: Reversed phase high performance liquid chromatographic method (RP-HPLC) was developed for determining the level of protopine in rats. The analytical column were packed with 5 mum C18. The mobile phase was a mixture of methanol, water and 10% acetic acid (80: 20: 2), in which the pH was modulated to 5.6 with 15% ammonia. Protopine biological samples were isolated well, in which two extraction with ether under basical condition and an extraction with 0.02 mol ¡¤ L-1 sulfuric acid were performed, respectively. The content of protopine in the biological sample was measured by an UV detector at 285 nm. The distrubution and excetion of protopine have been investigated in rats after intravenous administration 10 mg ¡¤ kg-1. RESULTS: Protopine distrubuted in many tissues after iv a dose of 10 mg ¡¤ kg-1. The higher level of protopine was found in lung, kidney, spleen and brain, and the highest was observed in lung at 5, 15 minutes after administration. However the top level tissue was testicle at 3 h, which may be due to small blood circulation. The excretion of the parent compound in urine was 36.87% of dose, but the excretion of the parent compound in feces and bile was less than 1% of dose. Plasma protein binding was less than 5%. CONCLUSION: The distrubution of protopine is extensive and the parent compoud was mainly excreted by urine and plasma protein binding was low.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1081-17-0, and how the biochemistry of the body works.Related Products of 1081-17-0
Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem