1081-17-0, Name is 1-(4-Methoxyphenyl)-1H-pyrrole-2,5-dione, belongs to pyrrolines compound, is a common compound. Product Details of 1081-17-0In an article, once mentioned the new application about 1081-17-0.
Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha
The alkaloidal components of the Bhutanese medicinal plant Corydalis calliantha Long, which is used for the treatment of malaria, have been assessed. Four known alkaloids, protopine (1), scoulerine (2), cheilanthifoline (3) and stylopine (4) are reported from this plant for the fi rst time. The protopine alkaloid, protopine, and the tetrahydroprotoberine alkaloid, cheilanthifoline, showed promising in vitro antiplasmodial activities against Plasmodium falciparum, both wild type (TM4) and multidrug resistant (K1) strains with IC50 values in the range of 2.78-4.29 muM. Such activity had not been demonstrated previously for cheilanthifoline. The results thus support, at a molecular level, the clinical use of this plant in the Bhutanese traditional medicine and identifi ed cheilanthifoline as a potential new antimalarial drug lead. Copyright
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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem