Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 119018-29-0, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 119018-29-0
A process of synthesizing glimepiride raw material (by machine translation)
The present invention discloses a process of synthesizing glimepiride raw material, in order to compound A: 3 – ethyl – 4 – methyl – 3 – pyrroline – 2 – one and compound, B: 2 – phenethyl isocyanate as the starting material, characterized in that intermediate 1 in the synthesis, the filtrate is applied so that the intermediate 1 to reduce the losses, improves the yield and the production efficiency; intermediate 2 in the synthesis, the hydrochloric ether as solvent, can greatly reduce the production of the impurity isomer, isomer impurity content from 8% to about 0.5% the following, so that the follow-up process is a purification operation; glimepiride in the synthesis of the metal salt, the b the nitrile does solvent, the reaction fully and time is greatly shortened, intermediate 3 residue from the original 5 – 10% reduced to 0.2% following and solvent recovery rate is high. The process of the invention is simple and safe, low production cost, high yield, intermediate and finished product quality stability, is suitable for industrial mass production and greater social and economic environmental benefits of the antihyperglycemic drug glimepiride synthesis process. (by machine translation)
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Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem