Application of 1585-90-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1585-90-6, Name is 1-(2-Hydroxyethyl)-1H-pyrrole-2,5-dione, molecular formula is C6H7NO3. In a Article£¬once mentioned of 1585-90-6
Bivalent bendamustine and melphalan derivatives as anticancer agents
The alkylating agents bendamustine and melphalan are currently used in the treatment of various tumoral diseases. In order to increase their antitumor potency and tumor selectivity both compounds were integrated in structure-activity relationship studies including new drug carrier systems. Here we describe the synthesis and the cytotoxicity of new bivalent bendamustine and melphalan derivatives. Two molecules each esterified with N-(2-hydroxyethyl) maleimide were connected by diamines with various chain lengths (n = 6, 7, 8, 12). It was supposed that these conjugates (5a-d, 10a-d, 11a-d) cause cytotoxic effects preferred as bivalent drug. Indeed the cytotoxicity of the new compounds increased compared to bendamustine and melphalan as determined in concentration-dependent in vitro assays using the human MCF-7 and MDA-MB-231 breast cancer cell lines.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1585-90-6, and how the biochemistry of the body works.Application of 1585-90-6
Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem