In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 73286-71-2, name is N-Boc-2-pyrroline, introducing its new discovery. COA of Formula: C9H15NO2
Enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine: The key to an efficient and practical synthesis of a glucokinase activator
(Chemical Equation Presented) A short and practical synthesis of glucokinase activator 1 was achieved utilizing a convergent strategy involving SNAr coupling of activated aryl fluoride 11 with hydroxypyridine 9. The key to the success of the synthesis was the development of a novel method for enantioselective formation of alpha-arylpyrrolidines during the course of the project. In this method, (-)-sparteine-mediated enantioselective lithiation of N-Boc-pyrrolidine was followed by in situ transmetalation to zinc and Pd-catalyzed coupling with aryl bromide 3, proceeding in 92% ee. This transformation allowed the preparation of compound 1 in a 31% overall yield over six steps.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 73286-71-2, and how the biochemistry of the body works.COA of Formula: C9H15NO2
Reference£º
Pyrroline – Wikipedia,
1-Pyrroline | C4H7N – PubChem