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Catalytic C(sp(2))-C(sp(3)) Bond Formation of Methoxyarenes by the Organic Superbase t-Bu-P4
The organic superbase catalyst t-Bu-P4 achieves nucleophilic aromatic substitution of methoxyarenes with alkanenitrile pronucleophiles. A variety of functional groups [cyano, nitro, (non)enolizable ketone, chloride, and amide moieties] are allowed on methoxyarenes. Moreover, an array of alkanenitriles with/without an aryl moiety at the nitrile alpha-position can be employed. The system also features no requirement of a stoichiometric base, MeOH (not salt waste) formation as a byproduct, and the production of congested quaternary carbon centers.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem