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REACTION OF ACYLPYRUVATE ESTERS WITH A MIXTURE OF AROMATIC ALDEHYDE AND 1,3-DIAMINOPROPANE AND PHARMACOLOGICAL ACTIVITY OF THE PRODUCTS
1-(3-Aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones (I – X) were prepared via reaction of methyl acylpyruvates and a mixture of aromatic aldehyde and 1,3-diaminopropane in a 1: 1: 1 molar ratio. The products were converted to hydrochlorides XI – XV in 48 – 90% yields. 1,3-Di(4-acetyl-3-hydroxy-2-oxo-5phenyl- 3-pyrrolin-1-yl) propane (XVI) was produced in 16% yield via reaction of methyl acetylpyruvate with a mixture of benzaldehyde and 1,3-diaminopropane in a 2: 2: 1 molar ratio. The biological activity of the 12 products was studied.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 107-97-1 help many people in the next few years. COA of Formula: C3H7NO2.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem