Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Safety of Di-tert-butyl chloromethyl phosphate229625-50-7, Name is Di-tert-butyl chloromethyl phosphate, SMILES is O=P(OC(C)(C)C)(OC(C)(C)C)OCCl, belongs to pyrrolines compound. In a article, author is Yu, Shuling, introduce new discover of the category.
Palladium-catalyzed tandem reaction of epoxynitriles with arylboronic acids in aqueous medium: divergent synthesis of furans and pyrroles
The efficient selective synthesis of furans and pyrroles has been realized by means of a palladium-catalyzed tandem addition/ring-opening/cyclization reaction of 2-(3-aryloxiran-2-yl)acetonitriles with arylboronic acids in aqueous medium for the first time. The chemoselectivity of this transformation can be predominantly governed by the steric effects of arylboronic acids: the reactions of 2-(3-aryloxiran-2-yl)acetonitriles with the less sterically hindered arylboronic acids provided furans as the sole products, while those of the sterically bulky arylboronic acids delivered pyrroles selectively. The O-18-labelled experiments revealed that the oxygen atom of furans is derived from water, and a plausible mechanism for this selective synthesis of furans and pyrroles was proposed.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 229625-50-7. Safety of Di-tert-butyl chloromethyl phosphate.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem