Synthetic Route of 274-09-9, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 274-09-9, Name is Benzo[d][1,3]dioxole, SMILES is C12=CC=CC=C1OCO2, belongs to pyrrolines compound. In a article, author is Dairi, Kenza, introduce new discover of the category.
A scalable process for the synthesis of the bcl inhibitor obatoclax
Recently we created the novel indolylprodigiosin derivative 2 (obatoclax) and demonstrated its ability to antagonize multiple members of the B-cell lymphoma (Bcl) family of antiapoptotic proteins. The compound has shown potent anticancer activity in several animal tumor models. Obatoclax is now in Phase 1b and 2 clinical trials directed against multiple hematologic and solid tumor malignancies. To support its clinical development, a new scalable synthesis was required. Obatoclax has been prepared using a three-step synthesis, starting from commercially available 4-methoxy-3-pyrrolin-2-one. The reaction sequence involves a haloformylation reaction followed by a Suzuki cross-coupling reaction with an indole-2-boronic acid. The synthesis is completed by an acid-mediated condensation with 2,4-dimethyl-1H-pyrrole.
Synthetic Route of 274-09-9, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 274-09-9.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem