Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 20880-92-6, Name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, molecular formula is , belongs to pyrrolines compound. In a document, author is Zhao, Xuna, Formula: C12H20O6.
In Situ Generated TEMPO Oxoammonium Salt Mediated Tandem Cyclization of beta-Oxoamides with Amine Hydrochlorides for the Synthesis of Pyrrolin-4-ones
A novel in situ generated TEMPO oxoammonium salt inediated one-pot tandem reaction has been developed for the straightforward construction of pyrrolin-4-ones from readily available beta-oxoamides with amine hydrochlorides. The reaction tolerates various functional groups and represents a reliable method for the synthesis of highly substituted pyrrolin-4-oes in good yields under mild conditions. Detailed mechanistic studies disclosed that TEMPO oxoammonium salt generated in situ was crucial for the transformation involving the formation of enaminone precursors in situ by condensation of the beta-oxoamides with amines, followed by sequential oxidative coupling with beta-oxoamides, intramolecular eyclization and 1,2-alkyl migration steps.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 20880-92-6, in my other articles. Formula: C12H20O6.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem