Application of 1240948-77-9, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 1240948-77-9, Name is 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile, SMILES is N#CC1=CNC(C2=CC=CC=C2F)=C1, belongs to pyrrolines compound. In a article, author is Shrivash, Manoj Kumar, introduce new discover of the category.
Water mediated procedure for preparation of stereoselective oximes as inhibitors of MRCK kinase
Stereoselective aldoximes, preferably Z form have been obtained from ci-cyano substituted carbonyl conjugated alkenes. This reaction occurs through Michael addition type reaction followed by retro-Knoevenagel reaction without transition-metal catalysis via C-C bond cleavage. These oximes are evaluated against cancer cell lines employing mechanistic study. Two oximes showed significant cytotoxic activity, which through in silico studies were found to inhibit MRCK Kinase, responsible for metastatic spread of cancer mortality. (C) 2020 Published by Elsevier B.V.
Application of 1240948-77-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 1240948-77-9.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem