Chemical Research Letters, May 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. Name: DL-alpha-Tocopherol,10191-41-0, Name is DL-alpha-Tocopherol, SMILES is CC1=C2C(OC(CCCC(CCCC(CCCC(C)C)C)C)(C)CC2)=C(C(C)=C1O)C, belongs to pyrrolines compound. In a document, author is Kholod, Inga, introduce the new discover.
Preparation of precursors for the synthesis of analogues of rhazinilam
Rhazinilam a structurally relatively simple tetracyclic natural product exerts interesting anticancer activities in vitro, which are difficult to reproduce in vivo. Based on the findings accumulated during the synthetic efforts and on the known metabolic sensitivity towards oxidation and acids a modified structural analogue of rhazinilam is proposed. A novel convergent approach towards the heterocyclic biaryl unit is described. The key sequence for the construction of 7 is the Mukaiyama crossed aldol reaction followed by the Staudinger reaction. Using known N-alkylation procedures the introduction of the side chains onto the 3-pyrrolin-2-one intermediate 2 needed for the construction of the tetracycle could not be achieved.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 10191-41-0. Name: DL-alpha-Tocopherol.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem