New research progress on 1707-03-5 in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 1707-03-5, Name is Diphenylphosphinic acid, molecular formula is C12H11O2P, belongs to pyrrolines compound, is a common compound. In a patnet, author is Gaston, Robert, Jr., once mentioned the new application about 1707-03-5, Recommanded Product: 1707-03-5.
Synthesis of Illudinine from Dimedone and Identification of Activity as a Monoamine Oxidase Inhibitor
The fungal metabolite illudinine is prepared in seven steps and ca. 55% overall yield from dimedone using an open and shut (ring-opening and ring-closing) strategy. Tandem ring-opening fragmentation and olefination of dimedone establishes alkyne and vinylarene functionality linked by a neopentylene tether. Oxidative cycloisomerization then provides the illudinine framework. The key innovation in this second-generation synthesis of illudinine is the use of the nitrile functional group, rather than an ester, as the functional precursor to the carboxylic acid of illudinine. The small, linear nitrile (C N) is associated with improved selectivity, pi-conjugation, and reactivity at multiple points in the synthetic sequence relative to the carboxylic acid ester. Preliminary assays indicate that illudinine and several related synthetic analogues are monoamine oxidase inhibitors, which is the first reported indication of biological activity associated with this natural product. Illudinine was found to inhibit monoamine oxidase B (MAO-B) with an IC50 of 18 +/- 7.1 mu M in preliminary assays.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms. 1707-03-5, you can contact me at any time and look forward to more communication. Recommanded Product: 1707-03-5.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem