New discoveries in chemical research and development in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. In an article, author is Lu, Yi, once mentioned the application of 578-95-0, Name is Acridin-9(10H)-one, molecular formula is C13H9NO, molecular weight is 195.22, MDL number is MFCD00005019, category is pyrrolines. Now introduce a scientific discovery about this category, Recommanded Product: Acridin-9(10H)-one.
A new process for the synthesis of nafoxidene as a key intermediate of lasofoxifene
A novel brief process for the synthesis of nafoxidene has been developed. The epoxidation of 6-methoxy-1-{4-[2-(pyrrolin-1-yl)ethoxy)]phenyl}-3,4-dihydronaphthalene by m-CPBA directly gave the ketone 6-methoxy-1-[4-(2-(pyrrolidin-1-yl)ethoxy) phenyl]-3,4-dihydronaphthalen-2(1H)-one, which was subject to phenyl magnesium bromide/cerium chloride and subsequently treated with an acid to yield nafoxidene. In addition, the preparation of the starting naphthalene was also optimized by replacing the aromatic lithium at low temperature with its Grignard reagent at refluxing THF. This mild process, without the use of toxic or noble metals, was more cost-efficient and easily worked up.
The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, their interactions with reaction intermediates. Interested yet? Read on for other articles about 578-95-0. Recommanded Product: Acridin-9(10H)-one.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem