New Advances in Chemical Research, May 2021.Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 20880-92-6, Name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, molecular formula is C12H20O6, belongs to pyrrolines compound, is a common compound. In a patnet, author is Inguimbert, N, once mentioned the new application about 20880-92-6, COA of Formula: https://www.ambeed.com/products/20880-92-6.html.
Unexpected formation of new chiral 3-amino-5-alkyl-2,5-dihydro-1H-pyrrolin-2-ones from N-Boc-alpha-amino esters
We describe a one-pot process involving the DiBA1-H reduction of the ester moiety of N-protected α-amino esters, followed by Horner-Wadsworth-Emmons olefination in the presence of the trimethyl ester phosphonoglycinate carbanion allowing the formation of new chiral 3-amino-5-alkyl-2,5-dihydro-IH pyrrolin-2-one 5. The Z-enoate 4b, which is formed during this reaction, could be converted into the corresponding lactam 5b under UV irradiation with the presence of BuLi. © 2005 Elsevier Ltd. All rights reserved.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 20880-92-6. COA of Formula: https://www.ambeed.com/products/20880-92-6.html.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem