New Advances in Chemical Research, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis.7423-55-4, Name is 3-Maleimidopropionic acid, molecular formula is C7H7NO4, belongs to pyrrolines compound, is a common compound. In a patnet, author is Wolinski, Przemyslaw, once mentioned the new application about 7423-55-4, HPLC of Formula: https://www.ambeed.com/products/7423-55-4.html.
Clean and molecularly programmable protocol for preparation of bis-heterobiarylic systems via a domino pseudocyclic reaction as a valuable alternative for TM-catalyzed cross-couplings
The domino sequence of pseudocyclic reactions involving 4-methoxybenzonitrile N-oxide and trans-2-phenyl-1-cyano-1-nitroethene proceeding in mild (r.t.; atm. pressure) non-catalytic (without participation of palladium or other transition metals (TM)) conditions yielded a bis-heterobiarylic molecular system containing an oxadiazole moiety with an almost 40% yield. The presented methodology represents therefore an evident contrast to the existing methods of preparation of bis-heterobiarylic systems, which require the presence of TMs. This reaction should be considered stereochemically clean and contains a stage of cycloaddition to the C=N bond. It should be underlined that this is the first case of non-catalyzed [3 + 2] cycloaddition involving the nitrile C=N bond. Our comprehensive study shows that the described protocol can be applied as a general methodology for preparation of a wide group of bis-heterobiarylic molecules. The self-adjusted cascade of transformations, which is unique and valuable from the practical point of view, leads to formation of a single isomeric product (from many possible) as a consequence of three pseudocyclic tandem reactions performed in agreement with the fundamental principles of green chemistry and sustainable development with a maximal level of atom economy and good overall yields. A self-adjustment phenomenon observed in the studied smart technology leading to production of a material with special properties was explained by it deep quantum nature confirmed undoubtedly by the modern Molecular Electron Density Theory. (C) 2020 Elsevier Ltd. All rights reserved.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms. 7423-55-4, you can contact me at any time and look forward to more communication. HPLC of Formula: https://www.ambeed.com/products/7423-55-4.html.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem