Chemical Research Letters, May 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 10191-41-0, Name is DL-alpha-Tocopherol, SMILES is CC1=C2C(OC(CCCC(CCCC(CCCC(C)C)C)C)(C)CC2)=C(C(C)=C1O)C, in an article , author is Dayam, Raveendra, once mentioned of 10191-41-0, Recommanded Product: 10191-41-0.
Substituted 2-pyrrolinone inhibitors of HIV-1 integrase
The beta-diketoacid class of HIV-1 integrase (IN) inhibitors represent the first potent class of compounds specific for the strand transfer catalytic activity of the viral enzyme. Previously, utilizing a beta-diketoacid pharmacophore as a search query, we identified a substituted 2-pyrrolinone with modest IN inhibitory activity from a database of small-molecules [Dayam, R.; Sanchez, T.; Neamati, N. J. Med. Chem. 2005, 48, 8009]. In efforts to optimize this class of IN inhibitors, we carried out a structure-activity relationship analysis around the 2-pyrrolinone core. Here, we present a new class of 2-pyrrolinone IN inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms. 10191-41-0, you can contact me at any time and look forward to more communication. Recommanded Product: 10191-41-0.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem