Chemical Research Letters, May 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world., SDS of cas: 56353-15-2, Introducing a new discovery about 56353-15-2, Name is (S)-2-(3-Acetamidopropanamido)-3-(1H-imidazol-4-yl)propanoic acid, molecular formula is C11H16N4O4, belongs to pyrrolines compound. In a document, author is Gein, V. L..
Synthesis and Analgesic Activity of 5-Aryl-4-Heteroyl-3-Hydroxy-1-(2-Thiazolyl)-3-Pyrrolin-2-Ones and their Derivatives
The three-component reaction of methyl 2-heteroylpyruvates with aromatic aldehydes and 2-aminothiazole was used to synthesize 5-aryl-4-(2-heteroyl)-3-hydroxy-1-(2-thiazolyl)-3-pyrrolin-2-ones. The corresponding 3-amino derivatives were obtained from the synthesized compounds by nucleophilic substitution with o-aminophenol, m-phenylenediamine, hydroxylamine, and urea; the corresponding pyrrolo[3, 4]pyrazoles, with hydrazine hydrate and phenylhydrazine. The structures of the new compounds were established using IR, PMR, and mass spectra and qualitative reactions. The acute toxicity and analgesic activity of the synthesized compounds were studied.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 56353-15-2. SDS of cas: 56353-15-2.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem