New research progress on 56-12-2 in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 56-12-2, Name is 4-Aminobutyric acid, molecular formula is C4H9NO2, belongs to pyrrolines compound, is a common compound. In a patnet, author is Mase, N, once mentioned the new application about 56-12-2, Quality Control of 4-Aminobutyric acid.
First synthesis of (R)-(-)-5-hydroxy-3-methyl-3-pyrrolin-2-one (jatropham) by lipase-catalyzed kinetic resolution
Jatropham, (R)-(-)-5-hydroxy-3-methyl-3-pyrrolin-2-one, is synthesized in three steps from citraconic anhydride. Highly regioselective reduction of citraconimide gives racemic jatropham in high yield. Kinetic resolution of racemic jatropham using lipase is also described. (C) 1999 Elsevier Science Ltd. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 56-12-2. Quality Control of 4-Aminobutyric acid.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem