New research progress on 83411-71-6 in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 83411-71-6, Name is Bis(2,4,4-trimethylpentyl)phosphinic acid, molecular formula is C16H35O2P, belongs to pyrrolines compound, is a common compound. In a patnet, author is Koszytkowska-Stawinska, Mariola, once mentioned the new application about 83411-71-6, Quality Control of Bis(2,4,4-trimethylpentyl)phosphinic acid.
Synthesis of 1-pyrroline 1-oxides analogous to pseudouridine
Pseudouridine (psi-uridine, Psi) aza’-analogues with a 5,5-bis(hydroxymethyl)-1-pyrrolin-2-yl 1-oxide as the glycone mimic were obtained by the addition of (2,4-dimethoxypyrimidin-5-yl)magnesium bromide to 1-aza-7,14-dioxadispiro[4.2.5.2]pentadec-1-ene 1-oxide (3), followed by oxidation and removal of the protecting groups. The analogous synthesis from (2,4-dimethoxypyrimidin-5-yl)lithium and 3 was less efficient; in the first step of the reaction sequence, competing dimerisation of 3 predominated over addition of the organolithium agent to 3. (C) 2011 Elsevier Ltd. All rights reserved.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 83411-71-6. Quality Control of Bis(2,4,4-trimethylpentyl)phosphinic acid.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem