New Advances in Chemical Research, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis.67604-48-2, Name is 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, molecular formula is C15H12O5, belongs to pyrrolines compound, is a common compound. In a patnet, author is Shrivash, Manoj Kumar, once mentioned the new application about 67604-48-2, Recommanded Product: 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one.
Water mediated procedure for preparation of stereoselective oximes as inhibitors of MRCK kinase
Stereoselective aldoximes, preferably Z form have been obtained from ci-cyano substituted carbonyl conjugated alkenes. This reaction occurs through Michael addition type reaction followed by retro-Knoevenagel reaction without transition-metal catalysis via C-C bond cleavage. These oximes are evaluated against cancer cell lines employing mechanistic study. Two oximes showed significant cytotoxic activity, which through in silico studies were found to inhibit MRCK Kinase, responsible for metastatic spread of cancer mortality. (C) 2020 Published by Elsevier B.V.
The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, their interactions with reaction intermediates. Interested yet? Read on for other articles about 67604-48-2. Recommanded Product: 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem