Electric Literature of 67604-48-2, New Advances in Chemical Research, May 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 67604-48-2, Name is 5,7-Dihydroxy-2-(4-hydroxyphenyl)chroman-4-one, SMILES is O=C1CC(C2=CC=C(O)C=C2)OC3=C1C(O)=CC(O)=C3, belongs to pyrrolines compound. In a article, author is Mateva, Rada, introduce new discover of the category.
MODULATING ACTION OF VITAMIN C ON THE CYTOTOXIC EFFECT OF MYOSMINE
Myosmine (3-(1-pyrrolin-2-yl)pyridine) is an alkaloid found in tobacco as well as in various foods, fruits and vegetables. Myosmine has recently been suspected to be a tobacco-independent carcinogenic source connected to the increase in incidence of esophageal adenocarcinoma. It has been shown that reactions of nitrosation and peroxidation of myosmine take part in its metabolic activation and leads to the formation of the esophageal carcinogens N’-nitrosonornicotine and 4-hydroxy-1-(3-pyridy1)-1-butanone. Increased cancerogenic potential of myosmine may be expected when the oxidative stress in the cell is enhanced. In order to examine the relationship between the oxidative status of the cells and the inhibitory action of myosmine on the cell growth we studied the combined effect of the antioxidant vitamin C and myosmine on cell proliferation as well as on the cell cycle of murine erythroleukemia (MEL) cells. Protective effect of vitamin C was found at incubation time of 48 hours. It was clearly observed that vitamin C had reduced the toxicity of myosmine in a wide range of concentrations. In order to see how cell cycle is affected in the presence of vitamin C and myosmine we conducted flow cytometric analysis. A combination of vitamin C with 100 mu M myosmine resulted in elimination of the effect of myosmine, respectively the histogram was almost identical to that of the control untreated cells. This result showed that the antioxidant had reduced the influence of myosmine on the cell cycle of MEL. At higher myosmine concentration (200 mu M) the addition of vitamin C reduced the amount of hypoploid cells almost in half. This could be connected with the smaller fraction of apoptotic cells. The conclusion can be drawn that vitamin C may protect cells from the cytotoxic effect of myosmine.
Electric Literature of 67604-48-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 67604-48-2 is helpful to your research.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem