New research progress on 95-45-4 in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 95-45-4, Name is Dimethylglyoxime, molecular formula is C4H8N2O2, belongs to pyrrolines compound, is a common compound. In a patnet, author is Kumon, Tatsuya, once mentioned the new application about 95-45-4, Quality Control of Dimethylglyoxime.
Practical Synthesis of alpha-Trifluoromethylated Pyridines Based on Regioselective Cobalt-Catalyzed [2+2+2] Cycloaddition using Trifluoromethylated Diynes with Nitriles
Regioselective cobalt-catalyzed [2+2+2] cycloaddition using fluorine-containing diynes with nitriles was described. Cycloaddition of fluorinated diynes with nitriles under the influence of CoCl2(phen), zinc bromide, and zinc dust in dichloroethane at 80 degrees C for 3 h took place smoothly, exclusively affording the corresponding alpha-fluoroalkylated pyridines in excellent yields. In addition, dinitriles as substrate were also found to be suitable for this reaction, giving the corresponding fluoroalkylated bipyridine derivatives in excellent yields.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms. 95-45-4, you can contact me at any time and look forward to more communication. Quality Control of Dimethylglyoxime.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem