New Advances in Chemical Research in 2021. Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage , causing turnover rates to depend strongly on interfacial structure. 1953-02-2, Name is Tiopronin, molecular formula is , belongs to pyrrolines compound. In a document, author is Wen, Hao, Formula: https://www.ambeed.com/products/1953-02-2.html.
Catalyst-Free [4+2] Cycloaddition of Ynamides with 2-Halomethyl Phenols To Construct 2-Amino-4H-Chromenes and alpha-Halo Enamides Simultaneously
We report the development of a facile protocol for the [4+2] cycloaddition of ynamides and 2-halomethyl phenols to afford the corresponding 2-amino-4H-chromenes and alpha-halo enamides under catalyst-free conditions. The reaction proceeds under mild conditions and exhibits good tolerance toward various functional groups and generates high yields. The plausible mechanism involves the formation of an active intermediate keteniminium as well as o-methylene quinone.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 1953-02-2. Formula: https://www.ambeed.com/products/1953-02-2.html.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem