Research speed reading in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 5306-85-4, Name is (3R,3aR,6S,6aR)-3,6-Dimethoxyhexahydrofuro[3,2-b]furan, molecular formula is C8H14O4. In an article, author is SIGMAN, MS,once mentioned of 5306-85-4, Safety of (3R,3aR,6S,6aR)-3,6-Dimethoxyhexahydrofuro[3,2-b]furan.
THE FIRST IRON-MEDIATED CATALYTIC CARBON-NITROGEN BOND FORMATION – [4+1] CYCLOADDITION OF ALLENYL IMINES AND CARBON-MONOXIDE
Catalytic carbon-nitrogen bond formation was achieved by iron carbonyls in the [4 + 1] cycloaddition of allenyl imines with CO. The Fe(CO)(5) photochemically catalyzed reaction of allenyl imines and CO gives preparatively useful yields of 3-alkylidene-4-pyrrolin-2-ones. These reactions take place under mild conditions and only require fluorescent light! Good control of alkylidene bond stereochemistry is achieved when the terminal allene groups are tert-butyl and methyl. Experiments in the dark show that stoichiometric Fe-2(CO)(9) can mediate [4 + 1] assembly by a purely thermal reaction to give good yields of the pyrrolinone products. These new methods for the construction of 3-alkylidene-4-pyrrolin-2-ones are complimentary to existing procedures and allow for a greater variety of alkylidene substituents.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 5306-85-4. Safety of (3R,3aR,6S,6aR)-3,6-Dimethoxyhexahydrofuro[3,2-b]furan.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem