You could be based in a university, combining chemical research with teaching; working on developing and trialing new drugs; or helping to ensure national healthcare provision keeps pace with new discoveries. 591-50-4, Name is Iodobenzene, molecular formula is C6H5I, belongs to pyrrolines compound, is a common compound. In a patnet, author is Vandekerckhove, Stephanie, once mentioned the new application about 591-50-4, Safety of Iodobenzene.
Synthesis of functionalized 3-, 5-, 6-and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity
(3-Pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines were prepared via cyclization of diallylaminoquinolines and 4-chloro-N-quinolinylbutanamides, respectively, as novel synthetic intermediates en route to N-functionalized 3-, 5-, 6- and 8-aminoquinolines with potential biological activity. (3-Pyrrolin-1-yl)quinolines were subjected to bromination reactions, and the reactivity of (2-oxopyrrolidin-1-yl)quinolines toward lithium aluminum hydride and methyllithium was assessed, providing an entry into a broad range of novel functionalized (pyrrolidin-1-yl)- and (hydroxyalkylamino) quinolines. Antiplasmodial evaluation of these novel quinolines and their functionalized derivatives revealed moderate micromolar potency against a chloroquine-sensitive strain of the malaria parasite Plasmodium falciparum, and the two most potent compounds also showed micromolar activity against a chloroquine-resistant strain of P. falciparum. Antifungal assessment of (hydroxyalkylamino)quinolines revealed three compounds with promising MIC values against Rhodotorula bogoriensis and one compound with potent activity against Aspergillus flavus. (C) 2014 Elsevier Masson SAS. All rights reserved.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules. In my other articles, you can also check out more blogs about 591-50-4. Safety of Iodobenzene.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem