Formula: https://www.ambeed.com/products/293298-33-6.html, Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. 293298-33-6, Name is 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanehydrazide hydrochloride, SMILES is O=C(NN)CCN1C(C=CC1=O)=O.[H]Cl, belongs to pyrrolines compound. In a article, author is Rodriguez-Soria, Veronica, introduce new discover of the category.
A novel stereoselective tin-free radical protocol for the enantioselective synthesis of pyrrolidinones and its application to the synthesis of biologically active GABA-derivatives
Optically pure 4-alkyl-pyrrolin-2-ones were synthesized from chiral N-allyl-alpha-bromoacetamides in high selective and stereo-controlled fashion, via a sequential 5-exo-trig radical cyclization-hydrogen or bromine atom-transfer process, under non-tin conditions. Interestingly, when N-allyl-alpha-bromoacetamides were treated with triethylborane/MeOH(excess)/BF3 center dot OEt2 in toluene at -78 degrees C, a tandem 5-exo-trig radical cyclization-hydrogen atom-transfer reaction operated, on the other hand, a tandem 5-evo-trig radical cyclization-bromine atom-transfer reaction proceeded in good yield and high stereoselectivity when the reaction was carried out with equimolar amounts of MeOH in THF at -78 degrees C. Thus, optically pure 4-alkyl-pyrrolin-2-ones were synthesized via this tin-free radical pathway and transformed to their corresponding biologically active GABA-derivatives, Pregabalin and CAMP. (C) 2008 Published by Elsevier Ltd.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 293298-33-6. Formula: https://www.ambeed.com/products/293298-33-6.html.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem