Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 29331-92-8, Name is 10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide, molecular formula is C15H14N2O2, belongs to pyrrolines compound, is a common compound. In a patnet, author is Qiu, Xiao-Feng, once mentioned the new application about 29331-92-8, Synthetic Route of 29331-92-8.
Late-Stage Transformation of Carboxylic Acids to N-Trifluoroethylimides with Trifluoromethyl Diazomethane
We report the first systematic evaluation of the reaction of trifluoromethyl diazomethane (2,2,2-trifluorodiazoethane, CF3CHN2) with drug-like molecules. We found our previous copper-catalyzed transformation of carboxylic acids to the corresponding N-trifluoroethylimides with CF3CHN2 and acetonitrile is well-suited for the latestage modification of drug and drug-like acids. A procedure that enables the use of solid nitriles and nitriles with high boiling points as viable substrates is also disclosed.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 29331-92-8 is helpful to your research. Synthetic Route of 29331-92-8.
Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem