Product Details of 95-45-4, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 95-45-4, Name is Dimethylglyoxime, SMILES is CC(/C(C)=N/O)=NO, belongs to pyrrolines compound. In a article, author is Kholod, Inga, introduce new discover of the category.
Preparation of precursors for the synthesis of analogues of rhazinilam
Rhazinilam a structurally relatively simple tetracyclic natural product exerts interesting anticancer activities in vitro, which are difficult to reproduce in vivo. Based on the findings accumulated during the synthetic efforts and on the known metabolic sensitivity towards oxidation and acids a modified structural analogue of rhazinilam is proposed. A novel convergent approach towards the heterocyclic biaryl unit is described. The key sequence for the construction of 7 is the Mukaiyama crossed aldol reaction followed by the Staudinger reaction. Using known N-alkylation procedures the introduction of the side chains onto the 3-pyrrolin-2-one intermediate 2 needed for the construction of the tetracycle could not be achieved.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem