The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, spectroscopic, and theoretical assessments of solvent structures and their interactions with reaction intermediates. 3317-61-1, Name is 5,5-Dimethyl-1-pyrroline N-oxide, molecular formula is C6H11NO, belongs to pyrrolines compound, is a common compound. In a patnet, author is Zhao, Xuna, once mentioned the new application about 3317-61-1, Application In Synthesis of 5,5-Dimethyl-1-pyrroline N-oxide.
In Situ Generated TEMPO Oxoammonium Salt Mediated Tandem Cyclization of beta-Oxoamides with Amine Hydrochlorides for the Synthesis of Pyrrolin-4-ones
A novel in situ generated TEMPO oxoammonium salt inediated one-pot tandem reaction has been developed for the straightforward construction of pyrrolin-4-ones from readily available beta-oxoamides with amine hydrochlorides. The reaction tolerates various functional groups and represents a reliable method for the synthesis of highly substituted pyrrolin-4-oes in good yields under mild conditions. Detailed mechanistic studies disclosed that TEMPO oxoammonium salt generated in situ was crucial for the transformation involving the formation of enaminone precursors in situ by condensation of the beta-oxoamides with amines, followed by sequential oxidative coupling with beta-oxoamides, intramolecular eyclization and 1,2-alkyl migration steps.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem