Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. 1240948-77-9, Name is 5-(2-Fluorophenyl)-1H-pyrrole-3-carbonitrile, molecular formula is , belongs to pyrrolines compound. In a document, author is Shrivash, Manoj Kumar, Electric Literature of 1240948-77-9.
Water mediated procedure for preparation of stereoselective oximes as inhibitors of MRCK kinase
Stereoselective aldoximes, preferably Z form have been obtained from ci-cyano substituted carbonyl conjugated alkenes. This reaction occurs through Michael addition type reaction followed by retro-Knoevenagel reaction without transition-metal catalysis via C-C bond cleavage. These oximes are evaluated against cancer cell lines employing mechanistic study. Two oximes showed significant cytotoxic activity, which through in silico studies were found to inhibit MRCK Kinase, responsible for metastatic spread of cancer mortality. (C) 2020 Published by Elsevier B.V.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem