Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 57-71-6, Name is Diacetyl Monoxime, molecular formula is C4H7NO2, belongs to pyrrolines compound, is a common compound. In a patnet, author is Dolfen, Jeroen, once mentioned the new application about 57-71-6, Synthetic Route of 57-71-6.
Concise Synthesis of 3-(Aminomethyl)pyrrolizidines via an In(OTf)(3)-Mediated Ring Rearrangement of 2-[2-(1-Pyrrolin-2-yl)alkyl]aziridines
In this study, an efficient ring rearrangement of 2-[2-(1-pyrrolin-2-yl)alkyl]aziridines, prepared from 2-(bromomethyl) aziridines, toward novel trans-and cis-3-aminomethyl-substituted pyrrolizidines was developed. To that end, addition of In(OTf)(3) as an appropriate Lewis acid catalyst resulted in the formation of intermediate pyrrolizidinium salts via regioselective aziridine ring opening, which were then trapped by a hydride or cyanide nucleophile. Column chromatographic purification allowed the isolation of the major trans-isomers, exclusively.
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Reference:
Pyrroline – Wikipedia,
,1-Pyrroline | C4H7N – PubChem